1 Introduction to Epidemiology
PATIENTS PROFILE
INTRODUCTION
PERSON�� PLACE�� & TIME
THE EPIDEMIOLOGIC APPROACH
THE APPLICATIONS OF EPIDEMIOLOGY
SUMMARY

2 Epidemiologic Measures
HEALTH SCENARIO
CLINICAL BACKGROUND
INTRODUCTION
MEASURES OF DISEASE OCCURRENCE
DISTINCTIONS BETWEEN MEASURES OF DISEASE FREQUENCY
SURVIVAL
SUMMARY

3 Global Burden of Disease
HEALTH SCENARIO
GLOBAL BURDEN OF DISEASE STUDY
SUMMARY

4 Descriptive Epidemiology
HEALTH SCENARIO
DESCRIPTNE EPIDEMIOLOGY
CORRELATIONS WITH DISEASE OCCURRENCE
MIGRATION AND DISEASE OCCURRENCES
MAJOR STUDY DESIGNS AND SOURCES OF DATA
SUMMARY

5 Cohort Study
PATIENT PROFILE
CLINICAL BACKGROUND
STUDY DESIGN
SELECTION OF SUBJECTS
DATA COLLECTION
ANALYSIS
SUMMARY
Case-Control Study
HEALTH SCENARIO AND CLINICAL BACKGROUND
INTRODUCTION
CASE
CONTROLS
MATCHING
EXPOSURE
ANALYSIS
SUMMARY
Clinical Trials
HEALTH SCENARIO
INTRODUCTION
CLINICAL TRIAL DESIGNS
CLINICAL TRIAL PHASES
STUDY PARTICIPANT SELECTION
RANDOMIZATION AND BLINDING
SAMPLE SIZE ESTIMATION
OUTCOMES AND ANALYSIS
ETHICAL ISSUES
CONCLUSIONS AND LIMITATIONS
SUMMARY
Diagnostic Testing
DESIGN OF STUDIES TO EVALUATE TEST PERFORMANCE
ACCURACY OF DIAGNOSTIC TEST
RELIABILITY OF DIAGNOSTIC TEST
EFFECTIVE OF A DIAGNOSTIC TEST
THE CUTOFF VALUE OF DIAGNOSTIC TEST
IMPROVE THE EFFICIENCY OF DIAGNOSTIC TEST
SCREENIG
SUMMARY

9 Variability and Bias
HEALTH SCENARIO
VARIABILITY IN MEDICAL RESEARCH
VALIDITY
SUMMARY

10 Interpretation of the Epidemiologic Literature
PATIENT PROFILE
INTRODUCTION
SEARCHING THE LITERATURE
REVIEWING INDIVIDUAL STUDIES
ESTABLISHING A CAUSAL RELATIONSHIP
DIETARY FAT AND BREAST CANCER
SUMMARY

11 Evidence-based Medicine and Systematic Review
HEALTH SCENARIO
EVIDENCE-BASED MEDICINE
THE FOUR COMPARATIVE EFFECTIVENESS APPROACHES
SYSTEMATIC REVIEWS�� UTILITY AND DEFINITION
SYSTEMATIC REVIEWS�� PLANNING AN SR
QUANTITATIVE SYSTEMATIC REVIEW DEFINITION
PERFORMING A QUANTITATIVE SYSTEMATIC REVIEW�� META-ANALYSIS
SUMMARY

12 Communicable Disease Epidemiology
HEALTH SCENARIO
INTRODUCTION
ETIOLOGY OF COMMUNICABLE DISEASE
INFECTIOUS PROCESS & SPECTRUM OF COMMUNICABLE DISEASE
PREVENTION AND CONTROL MEASURES FOR COMMUNICABLE DISEASES
SUMMARY

13 Noncommunicable Chronic Disease Epidemiology
OVERVIEW
INTRODUCTION TO THE MAJOR NCDS
RISK FACTORS
PREVENTION STRATEGIES AND INITIATIVES
PREVENTIVE MEASURES
NATIONAL AND GLOBAL PLAN
SUMMARY

Index